mTOR inhibitor-1

SKU: orb1301874

Description

C-4 is an ATP-competitive mTOR inhibitor that suppresses cellular growth and proliferation. This small molecule is utilized in biochemical and cell-based research to study mTOR signaling pathways in oncology and metabolic disease contexts, both in vitro and in vivo.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 468747-17-3
• MW: 363.21
• Purity: >99.99% (May vary between batches)
• Formula: C₁₆H₁₅BrN₂O₃
• SMILES: C\C(=N/NC(=O)c1ccc(C)c(Br)c1)c1ccc(O)cc1O
• Target: Autophagy,mTOR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.51 mM);DMSO:70 mg/mL (192.73 mM)

Bioactivity

• In Vitro:
  The addition of C-4 (mTOR inhibitor-1, 0~12.8 μg/ml) directly decreases the level of activated mTOR (p-mTORser2448) which is phosphorylated at Ser2448. The proliferation of A549 cells is strongly inhibited by C-4, and the inhibitory effect is time- and dose314 dependent. The IC50 of C-4 at 24 h is calculated as 3.176 μM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, mTOR inhibitor 1, mTOR inhibitor1, mTOR inhibitor-1, mTOR, inhibit, Inhibitor, Mammalian target of Rapamycin

Compound Identifiers

PubChem CID

135418721