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mTOR inhibitor-1

SKU: orb1301874

Description

C-4 is an ATP-competitive mTOR inhibitor that suppresses cellular growth and proliferation. This small molecule is utilized in biochemical and cell-based research to study mTOR signaling pathways in oncology and metabolic disease contexts, both in vitro and in vivo.

Research Area

Cell Biology, Pharmacology & Drug Discovery; Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number468747-17-3
MW363.21
Purity>99.99% (May vary between batches)
FormulaC16H15BrN2O3
SMILESC\C(=N/NC(=O)c1ccc(C)c(Br)c1)c1ccc(O)cc1O
TargetAutophagy,mTOR
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.51 mM);DMSO:70 mg/mL (192.73 mM)

Bioactivity

In Vitro
The addition of C-4 (mTOR inhibitor-1, 0~12.8 μg/ml) directly decreases the level of activated mTOR (p-mTORser2448) which is phosphorylated at Ser2448. The proliferation of A549 cells is strongly inhibited by C-4, and the inhibitory effect is time- and dose314 dependent. The IC50 of C-4 at 24 h is calculated as 3.176 μM.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Autophagy, mTOR inhibitor 1, mTOR inhibitor1, mTOR inhibitor-1, mTOR, inhibit, Inhibitor, Mammalian target of Rapamycin

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 110.00
10 mg
$ 140.00
25 mg
$ 230.00
50 mg
$ 340.00
100 mg
$ 540.00
DispatchUsually dispatched within 5-10 working days
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