PKCβ inhibitor 1

SKU: orb1298987

Description

KUN79359 is a potent, ATP-competitive, and selective inhibitor of PKCβ isozymes, demonstrating IC50 values of 21 nM and 5 nM for human PKCβ1 and PKCβ2, respectively. This compound is a valuable research tool for investigating PKCβ signaling in oncology, diabetic complications, and inflammatory disease models, both in vitro and in vivo.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 257879-35-9
• MW: 411.46
• Purity: 99.33%
• Formula: C₂₄H₂₁N₅O₂
• SMILES: O=C1NC(=O)C(=C1Nc1ccccc1)c1cn(CCCn2ccnc2)c2ccccc12
• Target: PKC,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.43 mM);DMSO:4.12 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  PKCβ1 (human):21 nM |PKCα:331 nM|PKCβ2 (human):5 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2F7, BCBL-1, ATP-competitive, Apoptosis, cell, mTOR, inhibit, Inhibitor, KUN79359, KUN-79359, KUN 79359, GSK3β, selective, PKC, PKCβ inhibitor 1, PKCβ inhibitor1, PKCβ inhibitor-1, PKCβ, PKCbeta inhibitor 1, PKCb inhibitor 1, phosphorylation, proliferation, Protein kinase C, tumor

Compound Identifiers

PubChem CID

6419755