Stabilin-1 Antibody

SKU: orb2568798

Description

mStab1-1.26, + is a mouse monoclonal antibody against mouse Stabilin-1 (UniProt entry: Q8R4Y4), also known as Clever-1 or FEEL-1. Stabilin-1 is a scavenger receptor expressed by sinusoidal endothelial cells (ECs) in the liver, lymph nodes, spleen, and bone marrow [1]. Stabilin-1 is expressed in human breast cancer and supports tumor growth [2]. It is found on subset of macrophages that mediate tissue homeostasis and is involved in liver fibrosis [3]. mStab1-1.26 or mStabilin-1 (clone 1.26) is first mentioned by Schledzewski et al. (2006) [4]. To generate the antibody, a recombinant mouse stabilin-1 fragment (residues 1–710 of Q8R4Y4) fused to mouse IgG2b-Fc was purified from stably-transfected HEK293 cells and used to immunize stabilin-1 knockout mice. mStab1-1.26 recognizes stabilin-1 in rat and mouse. The antibody is produced exclusively under serum-free conditions from hybridoma and purified through one-step purification with Protein-G affinity chromatography.

Images & Validation

• Tested Applications: In vivo
• Reactivity: Mouse, Rat
• Application Notes:
  Recomended Isotype: Mouse IgG1ĸ Isotype Control, Recomended Isotype Catalog: orb2568796

Key Properties

• Antibody Type: Primary Antibody
• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Clone No.: 1.26
• Immunogen: Recombinant mouse Stabilin-1 fragment from HEK 293 (residues 1–710 of Q8R4Y4, fused to mouse-IgG2b-Fc
• Target: Stabilin-1
• Purity: ≥ 90 % (CGE, reducing conditions) Endotoxin level ≤ 2 EU/mg
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
• Concentration: ≥ 1 mg/ mL
• Disclaimer: For research use only

Alternative Names

STABILIN-1, FEX1, SCARH2, FEEL-1, FEEL1, FELE-1, CLEVER-1, mouse stab1

Quick Database Links

Gene Symbol

Stabilin-1

UniProt

Q8R4Y4