MSAB

SKU: orb1298694

Description

MSAB

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 173436-66-3
• MW: 305.35
• Purity: 99.76% (May vary between batches)
• Formula: C₁₅H₁₅NO₄S
• SMILES: COC(=O)c1cccc(NS(=O)(=O)c2ccc(C)cc2)c1
• Target: Wnt/beta-catenin
• Solubility: DMSO:247.5 mg/mL (810.55 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.55 mM)

Bioactivity

• In Vivo:
  MSAB act against Wnt/β-catenin signaling and identified as a selective inhibitor of Wnt/β-catenin signaling. MSAB shows potent anti-tumor effects selectively on Wnt-dependent cancer cells in vitro and in mouse cancer models. MSAB binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. might represent an effective therapeutic strategy for cancers addicted to the Wnt/β-catenin signaling pathway.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

β-catenin, βcatenin, Wnt/betacatenin, Wnt/b-catenin, Wnt, Wnt/β-catenin, Inhibitor, inhibit, MSAB, Beta catenin, beta-catenin, betacatenin, degradation, anti-tumor, cancer, bcatenin

Compound Identifiers

PubChem CID

1159052