MSAB

SKU: orb1219572

Description

MSAB is a selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes.MSAB act against Wnt/β-catenin signaling and identified as a selective inhibitor of Wnt/β-catenin signaling. MSAB shows potent anti-tumor effects selectively on Wnt-dependent cancer cells in vitro and in mouse cancer models. MSAB binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. might represent an effective therapeutic strategy for cancers addicted to the Wnt/β-catenin signaling pathway.

Key Properties

• CAS Number: 173436-66-3
• MW: 305.35
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₅NO₄S
• SMILES: COC(=O)c1cccc(NS(=O)(=O)c2ccc(C)cc2)c1
• Target: Wnt/beta/catenin
• Solubility: In Vitro: DMSO : 250 mg/mL (818.73 mM)

Bioactivity

• In Vivo:
  MSAB (10-20 mg/kg; i.p. daily for 2 weeks) inhibits tumor growth of Wnt-dependent cancer cells in mouse xenograft model. MSAB (10-20 mg/kg; i.p. twice daily for 2 weeks) inhibits tumor growth of MMTV-Wnt1 transgenic mice. Animal model: Athymic nude mice (5-6 weeks) are injected HCT116, HT115, H23, or H460 cells. Dosage: 10, 20 mg/kg. Administration: i.p. dailyfor 2 weeks. Result: Reduced the size and weight of various types of Wnt-dependent HCT116, HT115, and H23 tumors.
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• In Vitro:
  MSAB (2-10 μM) selectively decreases cell viability of Wnt-dependent cells while showing little effect on Wnt-independent cells and normal human cells. MSAB (0.01-10 μM; 20 h) inhibits T-cell factor (TCF) luciferase reporter activity in HCT116 cells. MSAB (20 h) suppresses the Wnt3a-induced TOP-Luc activation and increases of active β-catenin levels in HEK293T cells. MSAB (0.5-10 μM; 20 h) decreases mRNA and protein levels of endogenous Wnt target genes in HCT116 cells. MSAB (5 μM; 16 h) induces degradation of β-catenin in a proteasome-dependent manner in HCT116 cells.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Wnt/beta/catenin