MS 154N

SKU: orb1741488

Description

MS 154N is a negative control compound for MS 154, exhibiting high binding affinity for both wild-type and L858R-mutant EGFR (Kd ~3-4.3 nM) without inducing significant mutant EGFR degradation. It serves as a critical tool for validating on-target effects in cellular and biochemical assays investigating EGFR-driven oncology research.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2675490-97-6
• MW: 915.45
• Formula: C₄₇H₅₆ClFN₈O₈
• SMILES: O=C1C=2C(C(=O)N1C3C(=O)N(C)C(=O)CC3)=CC=CC2OCCCCCCCCNC(CCN4CCN(CCCOC5=CC6=C(C=C5OC)N=CN=C6NC7=CC(Cl)=C(F)C=C7)CC4)=O
• Target: Others,PROTACs,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155515813