MS 15203

SKU: orb2900997

Description

MS15203 is a potent and selective GPR171 agonist. MS15203 increases food intake and body weight. MS15203 increases neuronal activity. MS15203 significantly increases the abundance of the mRNAs encoding proSAAS, NPY, AgRP.

Key Properties

• CAS Number: 73912-52-4
• MW: 249.22
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₁NO₅
• SMILES: O=C(O)C1=CC(=CC(=C1)C(=O)O)NC(=O)C(=C)C
• Target: GPR
• Solubility: In Vitro: DMSO : 50 mg/mL (200.63 mM; Ultrasonic (<60°C)

Bioactivity

• In Vivo:
  MS15203 (MS0015203) (3 mg/kg; i.p.) causes an increase in neuronal activity within cells containing GPR171 in the PVN.. MS15203 (3 mg/kg; i.p.) significantly increases food intake at 4 and 8 hours. MS15203 (3 mg/kg; i.p.) significantly increases the abundance of the mRNAs encoding proSAAS, NPY, AgRP.
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• In Vitro:
  MS15203 (MS0015203) dose-dependently increases [[35]S]GTPγS binding and inhibits adenylyl cyclase activity in rat hypothalamic membranes.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

GPR