MS 15203

SKU: orb1693135

Description

MS 15203

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 73912-52-4
• MW: 249.22
• Formula: C₁₂H₁₁NO₅
• SMILES: O=C(O)C1=CC(=CC(=C1)C(=O)O)NC(=O)C(=C)C
• Target: GPR
• Solubility: DMSO:40 mg/mL (160.5 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.03 mM)

Bioactivity

• Target IC50:
  b-LEN:80 ± 1 nM
• In Vivo:
  To examine the effects of long-term activation of GPR171, administered MS 15203 (2.5 mg/kg) to mice by intraperitoneal injection every third day and fed a high-fat diet to exacerbate the effects of the compound. Knockdown of GPR171 in the hypothalamus significantly at tenuated MS 15203-induced weight gain, implying that chronic administration of MS 15203 affects body weight through GPR171.
  Read more...
• In Vitro:
  To assess the selectivity of MS 15203 for GPR171, screened the ligand against a panel of 80 different transmembrane and soluble receptors, including ~70 GPCRs. MS 15203 dose-dependently displaced radiolabeled b-LEN from hypothalamic membranes with an affinity that was lower than that of b-LEN. IC50 = 80 ± 1 (nM).
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GPR171, MS0015203, MS-0015203, MS15203, MS-15203, MS 15203

Compound Identifiers

PubChem CID

773544