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MRK-016
Catalog Number: orb2893738
| Catalog Number | orb2893738 |
|---|---|
| Category | Small Molecules |
| Description | MRK-016 is a selective GABAA α5 receptor inverse agonist/ negative allosteric modulator, (IC50=3 nM) with the advantages of being orally available and penetrating the blood-brain barrier.MRK-016 increases long time period potentiation (LTP) in mouse hippocampal slices, with memory-improvement, antidepressant, and pain-treating effects. |
| MW | 368.39 |
| CAS Number | 342652-67-9 |
| Formula | C17H20N8O2 |
| SMILES | N=1N=C(C2=NOC(=C2)C)N3N=C(OCC4=NC=NN4C)C(=C3C1)C(C)(C)C |
| Storage | -20°C |
| Note | For research use only |
