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MRK-016

SKU: orb2893738

Description

MRK-016 is a selective GABAA α5 receptor inverse agonist/ negative allosteric modulator, (IC50=3 nM) with the advantages of being orally available and penetrating the blood-brain barrier.MRK-016 increases long time period potentiation (LTP) in mouse hippocampal slices, with memory-improvement, antidepressant, and pain-treating effects.

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Key Properties

CAS Number342652-67-9
MW368.39
Purity99.76%
FormulaC17H20N8O2
SMILESN=1N=C(C2=NOC(=C2)C)N3N=C(OCC4=NC=NN4C)C(=C3C1)C(C)(C)C
TargetGABA Receptor

Storage & Handling

Storage-20°C
DisclaimerFor research use only

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  • MRK-016 [orb611735]

    342652-67-9

    368.3931

    C17H20N8O2

    10 mg, 50 mg
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Protocol Information

MRK-016 (orb2893738)

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Available Sizes

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1 mg
$ 150.00
5 mg
$ 210.00
1 ml x 10 mM (in DMSO)
$ 220.00
10 mg
$ 270.00
25 mg
$ 370.00
50 mg
$ 450.00
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