Mps1-IN-3

SKU: orb1308013

Description

Mps1-IN-3 is a potent and selective small molecule inhibitor of MPS1 kinase with a reported IC50 of 50 nM. This compound is a valuable research tool for studying mitotic checkpoint function and has been utilized in both cellular and in vivo models of cancer to investigate potential therapeutic strategies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1609584-72-6
• MW: 537.63
• Purity: 99.85% (May vary between batches)
• Formula: C₂₆H₃₁N₇O₄S
• SMILES: COc1cc(ccc1Nc1nc(Nc2ccccc2S(=O)(=O)C(C)C)c2nc[nH]c2n1)N1CCC(O)CC1
• Target: Kinesin
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.72 mM);DMSO:60 mg/mL (111.6 mM)

Bioactivity

• Target IC50:
  Mps1:50 nM
• In Vivo:
  Mps1-IN-3 (2 mg/kg, i.v.) enhances the sensitivity of glioblastoma cells in murine tumor models, extends survival, and exhibits no toxicity.
• In Vitro:
  Mps1-IN-3 inhibits the proliferation of U251 glioblastoma cells (IC50: appr 5 μM). Mps1-IN-3 is an effective inhibitor of MPS1 kinase (IC50: 50 nM). Mps1-IN-3 (2 μM) can completely abrogates checkpoint.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Monopolar spindle 1, Mps1, Mps1 IN 3, Mps1IN3, Mps-1-IN-3, Mps1-IN-3, inhibit

Compound Identifiers

PubChem CID

91885443