Mps1-IN-3

SKU: orb1218707

Description

Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).

Key Properties

• CAS Number: 1609584-72-6
• MW: 537.63
• Purity: >98% (HPLC)
• Formula: C₂₆H₃₁N₇O₄S
• SMILES: O=S(C1=C(NC2=NC(NC3=CC=C(N4CCC(O)CC4)C=C3OC)=NC5=C2N=CN5)C=CC=C1)(C(C)C)=O
• Target: Kinesin
• Solubility: DMSO:5 mM

Bioactivity

• In Vivo:
  Mps1-IN-3 (2 mg/kg, i. v.) sensitizes glioblastoma cells in murine tumor models, with prolonged survival and no toxicity.
• In Vitro:
  Mps1-IN-3 is a potent MPS1 kinase inhibitor, with an IC50 of 50 nM. Mps1-IN-3 inhibits the proliferation of U251 glioblastoma cells with an IC50 of appr 5 μM. Mps1-IN-3 (2 μM) can completely abrogates checkpoint.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Kinesin