Mps1-IN-2

SKU: orb1307348

Description

Mps1-IN-2 is a potent, selective, and ATP-competitive small molecule inhibitor targeting both Mps1 and Plk1 kinases. It is a valuable chemical probe for studying mitotic checkpoint signaling and has been utilized in both in vitro biochemical assays and cellular studies to investigate cancer cell proliferation.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1228817-38-6
• MW: 480.6
• Purity: 99.40%
• Formula: C₂₆H₃₆N₆O₃
• SMILES: CCOc1cc(ccc1Nc1ncc2N(C)C(=O)CCN(C3CCCC3)c2n1)N1CCC(O)CC1
• Target: PLK,Kinesin
• Solubility: DMSO:14.3 mg/mL (29.75 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.08 mM)

Bioactivity

• Target IC50:
  PLK1:61 nM (Kd)|PLK4:3100 nM (Kd)|GAK:140 nM (Kd)|Mps1:145 nM|STK33:5000 nM (Kd)|PLK3:1600 nM (Kd)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Polo-like Kinase (PLK), PLK, inhibit, Mps1 IN 2, Mps1, Mps1IN2, Mps-1-IN-2, Mps1-IN-2, Monopolar spindle 1, Inhibitor

Compound Identifiers

PubChem CID

44968267