Mps1-IN-2

SKU: orb1226735

Description

Mps1-IN-2 is a potent Mps1 kianse inhibitor with IC50 value of 145 nM.

Key Properties

• CAS Number: 1228817-38-6
• MW: 480.6
• Purity: >98% (HPLC)
• Formula: C₂₆H₃₆N₆O₃
• SMILES: CCOC1=C(NC2=NC=C3N(C)C(=O)CCN(C4CCCC4)C3=N2)C=CC(=C1)N1CCC(O)CC1
• Target: Kinesin
• Solubility: DMSO: 10 mM

Bioactivity

• In Vitro:
  Mps1-IN-2 is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 145 nM and 12 nM. Mps1-IN-2 also shows high affinity for PLK1 and GAK with Kds of 61 and 140 nM, respectively, but shows little or no inhibition on other 352 member kinases. Mps1-IN-2 can induces bypass of a checkpoint-mediated mitotic arrest in U2OS cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Kinesin