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Mouse anti-MyeloHRP, clone 266-6K1 (Monoclonal)
Catalog Number: orb302115
| Catalog Number | orb302115 |
|---|---|
| Category | Antibodies |
| Description | Human Myeloperoxidase ELISA Kit |
| Species/Host | Mouse |
| Clonality | Monoclonal |
| Clone Number | 266-6K1 |
| Tested applications | ELISA, WB |
| Reactivity | Human |
| Isotype | IgG1 |
| Immunogen | Please contact us for more information. |
| Concentration | 100 ug/ ml |
| Dilution range | , |
| Conjugation | Unconjugated |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Buffer/Preservatives | PBS with 0.1% rAlbumin and 0.02% sodium azide |
| Alternative names | Anti-84 kDa myeloperoxidase antibody, anti-89 kDa Read more... |
| Background | The monoclonal antibody 266-6K1 recognizes human myeloperoxidase (MPO), an ~135 glycoprotein expressed in all cells of the myeloid linage. MPO functions as an α2β2 heteromultimer consisting of two heavy (α) and two light (β) chains of 55 and 15 kDa respectively. MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils (PMNs). It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defense of the organism through production of hypochlorous acid (HOCl), a potent oxidant. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Upon activation of neutrophils, MPO can be rapidly released and as such useful in body fluids as marker for inflammatory status. Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer, Alzheimer's disease, inflammatory bowel disease and multiple sclerosis. Autoimmune antibodies to MPO (so called ANCA) are involved in Wegenerâ€s disease. Since the discovery of MPO deficiency, initially regarded as rare and restricted to patients suffering from severe infections, MPO has attracted more clinical attention. |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
