Montelukast sodium

SKU: orb1307782

Description

Montelukast sodium

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 151767-02-1
• MW: 608.17
• Purity: 99.29%
• Formula: C₃₅H₃₅ClNNaO₃S
• SMILES: C(S[C@@H](c1cc(/C=C/c2nc3c(cc2)ccc(c3)Cl)ccc1)CCc1c(cccc1)C(O)(C)C)C1(CC1)CC(=O)[O-].[Na+]
• Target: Leukotriene Receptor,LTR
• Solubility: H2O:30.4 mg/mL (49.99 mM);DMSO:250 mg/mL (411.07 mM)

Bioactivity

• In Vivo:
  Montelukast acts by binding to the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchi, thereby blockin the effects of leukotriene D4. This action prevents airway edema, smooth musclee contraction, and secretion of viscous liquids, reduces bronchoconstriction caused by leukotrienes, and diminishes inflammation occurrence.
• In Vitro:
  Administering 6 mg/kg of Montelukast once daily for 20 days significantly inhibit the increase of eosinophils in bot the BAL fluid and lung tissue in mice stimulated by OVA, while also elevatin the IL-5 levels in the BAL fluid. OVA stimulation leads to an upsurge in CysLT1 receptor mRNA expression but a decrease in CysLT2 receptor mRNA expression. Following OVA stimulation, Montelukast suppresse the elevated expression of CysLT1 without diminishin the expression of CysLT2.
• Cell Research:
  Nasal mucosa and polyp epithelial cells are stimulated with fetal bovine serum (FBS) with or without MK for 24 hours, and cytokine concentration in epithelial secretions are measured by ELISA. After incubating peripheral blood eosinophils with epithelial cell-conditioned media (ECM) with or without montelukast up to 3 days, eosinophil survival is assessed by Trypan blue dye exclusio.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

damage, cysteinyl, CysLTR1, Cysltr1, antioxidant, asthma, ischemia–reperfusion, intestinal, Montelukast, Montelukast sodium, liver, inhibit, MK 0476, MK0476, MK-0476, leukotriene, Leukotriene Receptor, LeukotrieneReceptor, Inhibitor, icardiac, injury

Compound Identifiers

PubChem CID

23663996