Monomethyl auristatin E

SKU: orb1223121

Description

MMAE, also known as Monomethyl auristatin E, is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. MMAE is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. MMAE show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer.

Key Properties

• CAS Number: 474645-27-7
• MW: 717.98
• Purity: >98% (HPLC)
• Formula: C₃₉H₆₇N₅O₇
• SMILES: C(=O)([C@H](C(C)C)NC(=O)[C@H](C(C)C)NC)N(C)[C@H]([C@@H](CC(=O)N1[C@@H](CCC1)[C@@H]([C@H](C(=O)N[C@@H]([C@H](c1ccccc1)O)C)C)OC)OC)[C@H](CC)C
• Target: Gamma-secretase
• Solubility: DMSO : ≥ 48 mg/mL; 66.85 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MMAE | Vedotin | Monomethyl auristatin E

Quick Database Links

Gene Symbol

Gamma-secretase