PNU-159682 Rabbit Monoclonal Antibody

SKU: orb2999611

Description

PNU-159682 is a topoisomerase II inhibitor serving as a payload for antibody-drug conjugates (ADCs). Its mechanism of action involves stabilizing the complex formed by topoisomerase II and DNA, blocking DNA repair and replication processes, and thereby inducing cancer cell apoptosis. Some ADCs containing PNU-159682 have entered the preclinical research stage, showing targeted killing activity in solid tumor models, with particularly significant effects on tumors with high topoisomerase II expression.

Images & Validation

• Reactivity: Rabbit

Key Properties

• Host: Human
• Clonality: Monoclonal
• Isotype: Rabbit IgG | Rabbit Kappa
• Clone No.: M1E11
• Target: PNU-159682
• Source/Expression System: HEK293
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: Powder
• Buffer/Preservatives: PBS, pH 7.4
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PNU-159682