DM-1 Rabbit Monoclonal Antibody

SKU: orb2999618

Description

DM1, a maytansinoid derivative, is a common payload toxin in antibody-drug conjugates (ADCs). It binds to tubulin, hinders microtubule assembly, arrests cell division, and induces apoptosis, but has off-target toxicity. ADCs like T-DM1 have shown good efficacy in HER2-positive cancers. For recent progress, many new DM1-containing ADCs are under development. For example, GQ1001 has entered Phase I clinical trials for HER2+ advanced solid tumors, and some have demonstrated antitumor activity in T-DM1-resistant models in preclinical studies.

Images & Validation

• Reactivity: Rabbit

Key Properties

• Host: Human
• Clonality: Monoclonal
• Isotype: Rabbit IgG | Rabbit Kappa
• Clone No.: M5D04
• Target: DM-1
• Source/Expression System: HEK293
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: Powder
• Buffer/Preservatives: PBS, pH 7.4
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DM-1