MnTBAP chloride

SKU: orb2900969

Description

MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research.

Key Properties

• CAS Number: 55266-18-7
• MW: 876.13
• Purity: >98% (HPLC)
• Formula: C₄₈H₂₅ClMnN₄O₈
• SMILES: [H+].O=C([O-])C=1C=CC(=CC1)C2=C3C=CC=4C(C=5C=CC(=CC5)C(=O)[O-])=C6C=CC7=C(C8=CC=C(C=C8)C(=O)[O-])C=9C=CC%10=C(C%11=CC=C(C=C%11)C(=O)[O-])C%12=CC=C2[N-]%12[Mn+3]([Cl-])([N]34)([N]%109)[N-]67
• Target: Antioxidant
• Solubility: In Vitro: DMSO : 100 mg/mL (113.75 mM; Ultrasonic )0.5 M NaOH : 20 mg/mL (22.75 mM; Ultrasonic)1M NaOH : 10 mg/mL (11.37 mM; ultrasonic and adjust pH to 8 with NaOH)

Bioactivity

• In Vivo:
  Animal model: C57BL/6J mice with 5/6 nephrectomy (Nx). Dosage: 10 mg/kg. Administration: IP; three times per week for twelve weeks. Result: Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Antioxidant