MnTBAP

SKU: orb1692254

Description

MnTBAP chloride is a cell-permeable manganese porphyrin complex functioning as a SOD mimetic and peroxynitrite scavenger. It demonstrates anti-inflammatory and antioxidant properties in research models, showing potential for studying fibrotic mechanisms in chronic kidney disease and other oxidative stress-related pathologies.

Research Area

Cell Biology

Key Properties

• CAS Number: 55266-18-7
• MW: 879.2
• Purity: >98%
• Formula: C₄₈H₂₈MnN₄O₈ · Cl
• SMILES: [H+].O=C([O-])C=1C=CC(=CC1)C2=C3C=CC=4C(C=5C=CC(=CC5)C(=O)[O-])=C6C=CC7=C(C8=CC=C(C=C8)C(=O)[O-])C=9C=CC%10=C(C%11=CC=C(C=C%11)C(=O)[O-])C%12=CC=C2[N-]%12[Mn+3]([Cl-])([N]34)([N]%109)[N-]67
• Target: SOD (superoxide dismutase)
• Solubility: Soluble in 0.1N NaOH

Bioactivity

• In Vivo:
  Local administration of MnTBAP significantly and reduced carrageenan-induced paw oedema dose-dependently at all time points, which was related to its superoxide dismutase mimetic property. MnTBAP also caused a significant dose-dependent reduction in paw myeloperoxidase activity, as well as preventing histological injury. Immunohistochemical analyses for nitrotyrosine showed a positive staining in paw from carrageenan-treated rats.
• In Vitro:
  Due to its superoxide dismutase mimetic property, 50 microM MnTBAP was found to attenuate the injury produced dose-dependently by exposure to various concentrations of paraquat for 4 h. MnTBAP also protected endothelial cells in a dose-dependent manner against paraquat. The protective effect of MnTBAP appears to be caused by its intracellular superoxide-scavenging activity because neither the zinc form nor CuZnSOD protected the cells against paraquat-induced injury.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NFκB, NF-κB, NF-kB, NFkB, MnTBAP Chloride, Mn(III)TBAP, Antioxidant

Quick Database Links

Gene Symbol

SOD (superoxide dismutase)