MN-64

SKU: orb1304467

Description

MN-64 is a potent and selective tankyrase 1 inhibitor (IC50 = 6 nM) that effectively suppresses Wnt/β-catenin signaling. This small molecule is a valuable chemical probe for studying Wnt-driven pathologies, including cancer, in both cellular and animal models.

Research Area

Epigenetics & Chromatin, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 92831-11-3
• MW: 264.32
• Purity: 99.63%
• Formula: C₁₈H₁₆O₂
• SMILES: CC(C)c1ccc(cc1)-c1cc(=O)c2ccccc2o1
• Target: PARP,Wnt/beta-catenin
• Solubility: DMSO:12 mg/mL (45.4 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.57 mM)

Bioactivity

• Target IC50:
  ARTD2:39.4 μM|TNKS2:72 nM|ARTD1:19.1 μM|TNKS1:6 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

betacatenin, beta-catenin, bcatenin, inhibit, PARP, MN64, MN-64, MN 64, Inhibitor, βcatenin, Tankyrase, TNKS1, TNKS2, Wnt/betacatenin, Wnt/b-catenin, Wnt, Wnt/β-catenin, poly ADP ribose polymerase

Compound Identifiers

PubChem CID

2802462