MN-64

SKU: orb1222989

Description

MN-64 is a potent and selective inhibitor of Tankyrase 1 and 2 (IC50 = 6 and 72 nM, respectively). MN-64 blocks Wnt signaling in HEK293 cells containing a Wnt pathway reporter system. Tankyrases are ADP-ribosyltransferases that play key roles in various cellular pathways, including the regulation of cell proliferation, and thus, they are promising drug targets for the treatment of cancer.

Key Properties

• CAS Number: 92831-11-3
• MW: 264.32
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₆O₂
• SMILES: CC(C)c1ccc(cc1)c1cc(=O)c2ccccc2o1
• Target: Gamma-secretase
• Solubility: DMSO : 100 mg/mL. 378.33 mM

Bioactivity

• In Vitro:
  MN-64 is a potent tankyrase 1 inhibitor, with IC50s of 6 nM, 72 nM, 19.1 μM, 39.4 μM for TNKS1, TNKS2, ARTD1 and ARTD2, respectively. MN-64 effectively inhibits Wnt/β-catenin at 1 μM, and blocks STF luciferase activity at 200 nM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MN-64 | MN 64 | MN64

Quick Database Links

Gene Symbol

Gamma-secretase