MMS21 (N) Antibody, Rabbit Polyclonal

SKU: orb67031

Description

Rabbit polyclonal to MMS21.MMS21 is also known as E3 SUMO-protein ligase NSE2E3, which is a SUMO-protein ligasecomponent of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks byhomologous recombination. The complex may promote sister chromatid homologous recombinationby recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. MMS21 acts as a E3 ligasemediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesincomponents RAD21 and STAG2. The SUMO protein-ligase activity of MMS21 is required for theprevention of DNA damage-induced apoptosis by facilitating DNA repair.

Images & Validation

• Tested Applications: WB
• Dilution range: WB:1:1000-1:5000
• Reactivity: Human

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: N-terminal region of human MMS21
• Molecular Weight: 28
• Purity: Affinity purification

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Disclaimer: For research use only

Alternative Names

anti-MMS21 antibody,anti-E3 SUMOprotein ligase NSE2 antibody,anti-MMS21 homolog antibody,anti-hMMS21 antibody,anti-Nonstructural maintenance of chromosomes element 2 homolog antibody,anti-NonSMC element 2 homolog antibody,anti-NSMCE2 antibody,anti-C8orf36 antibody,anti-MMS21 antibody

Western blot analysis of total cell extracts from human MCF7 using MMS21 antibody

Quick Database Links

UniProt

Q96MF7