Mc-MMAD

SKU: orb1988059

Description

Mc-MMAD is a maleimidocaproyl-modified derivative of the potent tubulin inhibitor monomethyl auristatin D (MMAD). This cytotoxic payload is widely utilized in antibody-drug conjugate (ADC) research for targeted cancer therapy, enabling the evaluation of drug efficacy in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 1401963-15-2
• MW: 964.26
• Purity: 98.04% (May vary between batches)
• Formula: C₅₁H₇₇N₇O₉S
• SMILES: [H][C@]([C@@H](C)CC)([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)c1nccs1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCN1C(=O)C=CC1=O)C(C)C
• Target: Ligands for Target Protein for PROTAC,Drug-Linker Conjugates for ADC,Microtubule Associated,ADC Cytotoxin
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.07 mM);DMSO:≥ 80 mg/mL

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Auristatin, DrugLinkerConjugatesforADC, DrugLinker Conjugates for ADC, Mc MMAD, McMMAD, Mc-MMAD

Compound Identifiers

PubChem CID

78357802