ML348

SKU: orb1304201

Description

ML348 (GNF-Pf-1127) is a potent, selective, and reversible inhibitor of lysophospholipase 1 (LYPLA1) with an IC50 of 210 nM. This small molecule is a valuable chemical probe for investigating LYPLA1's role in lipid signaling and metabolism in cellular and biochemical studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 899713-86-1
• MW: 415.79
• Purity: 99.88% (May vary between batches)
• Formula: C₁₈H₁₇ClF₃N₃O₃
• SMILES: FC(F)(F)c1ccc(Cl)c(NC(=O)CN2CCN(CC2)C(=O)c2ccco2)c1
• Target: Phospholipase
• Solubility: DMSO:83.33 mg/mL (200.41 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (7.94 mM)

Bioactivity

• Target IC50:
  LYPLA1:210 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LYPLA1, ML 348, ML348, ML-348, inhibit, GNF-Pf-1127, Inhibitor, Phospholipase

Compound Identifiers

PubChem CID

3238952