ML348

SKU: orb1223004

Description

ML348, also known as CID 3238952; SID 160654487, is a reversible LYPLA1 inhibitor with an IC50 value of 210 nM. Multiple oncogenes, including HRAS and SRC, require palmitoylation for malignant transformation. Lysophospholipase 1 (LYPLA1) has been identified as a candidate protein palmitoyl thioesterase responsible for HRAS depalmitoylation in mammalian cells.(In Vitro):ML348 (5 μM; 3 hours ) selectively inhibits LYPLA1 in cultured cells.(In Vivo):ML348 (50 mg/kg, i.p., 3 hours) shows potent and selective activity in vivo, inhibits LYPLA1 enzymes in heart, kidney and lung in mice.

Key Properties

• CAS Number: 899713-86-1
• MW: 415.79
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₇ClF₃N₃O₃
• SMILES: N1(CCN(CC(=O)Nc2c(ccc(c2)C(F)(F)F)Cl)CC1)C(=O)c1ccco1
• Target: FGFR
• Solubility: DMSO : 25 mg/mL. 60.13 mM

Bioactivity

• In Vivo:
  ML348 (50 mg/kg, i.p. , 3 hours) shows potent and selective activity In vivo, inhibits LYPLA1 enzymes in heart, kidney and lung in mice. Animal model: C57BL6 male mice (3-4 months). Dosage: 50 mg/kg. Administration: Intraperitoneal injection; 3 hours. Result: Potent and selective inhibited LYPLA1 enzymes in heart, kidney and lung In vivo.
• In Vitro:
  ML348 (5 μM; 3 hours ) selectively inhibits LYPLA1 in cultured cells. Cell Viability Assay Cell line: HEK293T cells, murine T-cells. Concentration: 5 μM. Incubation time: 3 hours. Result: Show potent, selective inhibition of LYPLA1.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ML348 | ML-348 | CID 3238952 | SID 160654487

Quick Database Links

Gene Symbol

FGFR