ML335

SKU: orb1223041

Description

ML335 is a potent and selective TREK-1/2 Activator. ML335 is an agonist for OPRM1-OPRD1 heterdimerization with an EC50 of 403 nM, and selectivities vs. OPRM1, OPRD1, and HTR5A of 37, 2.7, and >99, respectively.

Key Properties

• CAS Number: 825658-06-8
• MW: 373.25
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₄Cl₂N₂O₃S
• SMILES: CS(=O)(=O)Nc1ccc(cc1)C(=O)NCc1c(cc(cc1)Cl)Cl
• Target: Calcium Channel
• Solubility: DMSO : 155 mg/mL. 415.27 mM

Bioactivity

• In Vitro:
  Xenopus oocyte two-electrode voltage-clamp measurements show that ML335 and ML402 activate K2P2.1 and K2P10.1 but not K2P4.1 (14.3±2.7 μM, K2P2.1-ML335; 13.7±7.0 μM, K2P2.1-ML402; 5.2±0.5 μM, K2P10.1-ML335; and 5.9±1.6 μM, K2P10.1-ML402). Swapping the Lys271 equivalent between K2P2.1 and K2P4.1 results in a clear phenotype reversal for ML335 and M402 activation. ML335 and ML402 activate K2P2.1 in HEK293 cells similar to their effects in Xenopus oocytes (5.2±0.8 μM and 5.9±1.6 μM for ML335 and ML402, respectively (n≥3)).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ML335 | ML-335 | ML 335 | TREK-1/2 Activator

Quick Database Links

Gene Symbol

Calcium Channel