ML277

SKU: orb1304339

Description

ML277 (CID-53347902) is a potent and selective small molecule activator of KCNQ1 potassium channels, exhibiting an EC₅₀ of 260 nM. This compound is a valuable research tool for investigating channel function in cardiovascular and metabolic diseases, supporting both in vitro electrophysiology studies and in vivo physiological research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1401242-74-7
• MW: 471.6
• Purity: >98%
• Formula: C₂₃H₂₅N₃O₄S₂
• SMILES: COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(C)cc2)n1
• Target: Ion channel
• Solubility: Soluble in DMSO (up to 20 mg/ml)

Bioactivity

• Target IC50:
  K+ channel:270 nM
• In Vitro:
  ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM. IC50 value: 270 nM (EC50) Target: K(v)7.1 activator ML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(R)-N-(4-(4-Methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide

Compound Identifiers

PubChem CID

53347902