ML277

SKU: orb1218854

Description

ML277 was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).

Key Properties

• CAS Number: 1401242-74-7
• MW: 471.6
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₅N₃O₄S₂
• SMILES: O=C([C@@H]1N(S(=O)(C2=CC=C(C)C=C2)=O)CCCC1)NC3=NC(C4=CC=C(OC)C=C4)=CS3
• Target: Potassium Channel
• Solubility: DMSO:≥60 mg/mL (127.23mM)

Bioactivity

• In Vitro:
  ML277 (1 μM) increases the amplitude of KCNQ1 whole-cell and single-channel currents.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CID-53347902

Quick Database Links

Gene Symbol

Potassium Channel