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ML221

SKU: orb1223012

Description

ML221 is a potent apelin /APJ functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.

Images & Validation

Key Properties

CAS Number877636-42-5
MW385.35
Purity>98% (HPLC)
FormulaC17H11N3O6S
SMILESC1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-]
TargetAPJ
SolubilityDMSO : ≥ 31 mg/mL; 80.45 mM

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ML221 | ML 221 | ML-221

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  • ML221 [orb1302896]

    97.74% (May vary between batches)

    877636-42-5

    385.35

    C17H11N3O6S

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO)
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Protocol Information

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200 mg
500 mg
5 mg
$ 100.00
10 mg
$ 140.00
25 mg
$ 280.00
50 mg
$ 410.00
100 mg
$ 730.00