ML 254

SKU: orb1298573

Description

ML254 is a selective, competitive mGlu5 receptor antagonist that binds at the MPEP allosteric site. It exhibits a clean off-target profile and suitable pharmacokinetic properties for in vivo studies, facilitating research into neurological disorders such as anxiety, addiction, and Fragile X syndrome in rodent models.

Research Area

Neuroscience

Key Properties

• CAS Number: 1428630-86-7
• MW: 310.32
• Purity: 99.94% (May vary between batches)
• Formula: C₁₈H₁₅FN₂O₂
• SMILES: CC1(COC1)NC(=O)c1ccc(cn1)C#Cc1cccc(F)c1
• Target: GluR
• Solubility: DMSO:27.5 mg/mL (88.62 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.44 mM)

Bioactivity

• Target IC50:
  mGluR5 (rat):8.03 nM (pEC50)|mGluR5 (rat):9.3 nM (EC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Metabotropic glutamate receptors, mGluR5, mGluR, ML254, ML-254, ML 254, Schizophrenia

Compound Identifiers

PubChem CID

53382545