MK2-IN-3

SKU: orb1298427

Description

MK2-IN-3 is a cell-permeable, potent inhibitor of MAPKAP-K2 (MK2). It is utilized in research for rheumatoid arthritis and inflammation, showing efficacy in both cellular assays and animal models of inflammatory disease.

Research Area

Signal Transduction

Key Properties

• CAS Number: 724711-21-1
• MW: 340.38
• Purity: 99.01% (May vary between batches)
• Formula: C₂₁H₁₆N₄O
• SMILES: O=C1NCCc2[nH]c(cc12)-c1ccnc(c1)-c1cnc2ccccc2c1
• Target: MAPK
• Solubility: DMSO:9 mg/mL (26.44 mM)

Bioactivity

• Target IC50:
  MNK1:5.7 μM (IC50)|MK3:210 nM (IC50)|MK2:8.5 nM (IC50)|ERK2:3.44 μM (IC50)|MK5:81 nM (IC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TNFα, Inhibitor, MAP kinase activated protein kinase 2, MAPKAPK2 (MK2), MAPKAP-K2, MAPK, MAPK activated protein kinase 2, MAPKAP kinase 2, ERK2, inhibit, MNK1, Mitogen-activated protein kinase activated protein kinase 2, MK-5, MK2 IN 3, MK2 Inhibitor III, MK-2, MK-3, MK2IN3, MK-2-IN-3, MK2-IN-3

Compound Identifiers

PubChem CID

10389239