MK2-IN-3 hydrate

SKU: orb1309418

Description

MK2-IN-3 hydrate is a potent, selective, and orally bioavailable ATP-competitive inhibitor of MAPKAP-K2 (MK-2), exhibiting an IC50 of 0.85 nM. This small molecule is a valuable research tool for investigating MK-2 signaling in inflammatory diseases and cancer, with utility in both cellular and animal models of these conditions.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1186648-22-5
• MW: 358.39
• Purity: 99.14%
• Formula: C₂₁H₁₈N₄O₂
• SMILES: O=C1C2=C(NC(C3=CC(C4=CC5=CC=CC=C5N=C4)=NC=C3)=C2)CCN1.[H]O[H]
• Target: ERK,MNK,MAPK
• Solubility: DMSO:65 mg/mL (181.37 mM)

Bioactivity

• Target IC50:
  MNK1:5.7 μM|MK2:0.85 nM|MK3:0.21 μM|ERK2:3.44 μM|MK5:0.081 μM
• In Vitro:
  MK-2 Inhibitor III suppresses TNFα production (IC50 of 4.4 μM, in U397 cells).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MAP kinase activated protein kinase 2, MAPK activated protein kinase 2, MAPKAP kinase 2, MAPKAPK2 (MK2), ERK2, Mitogen-activated protein kinase activated protein kinase 2, MK5, MK-5, MK-3, MK-2 Inhibitor III, MK2 IN 3 hydrate, MK2IN3 hydrate, MK-2-IN-3 hydrate, MK2-IN-3 Hydrate, MK3, MK2, MK-2, MNK1, inhibit, Inhibitor

Compound Identifiers

PubChem CID

25163932