MK-8353

SKU: orb1309415

Description

MK-8353

Research Area

Signal Transduction

Key Properties

• CAS Number: 1184173-73-6
• MW: 691.84
• Purity: 96.15%
• Formula: C₃₇H₄₁N₉O₃S
• SMILES: CS[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2)-c2ncn(C)n2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccc(OC(C)C)nc3)c2c1
• Target: ERK
• Solubility: DMSO:125 mg/mL (180.68 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (5.78 mM)

Bioactivity

• Target IC50:
  ERK1:23 nM|ERK2:8.8 nM
• In Vivo:
  MK-8353 causes at least 50% tumor growth inhibition or regression in 83% of the animal models bearing different tumor cells.
• In Vitro:
  MK-8353 is a potent, selective, and orally available ERK1/2 inhibitor with IC50 values of 23.0 nM and 8.8 nM, respectively; it exhibits antitumor activity.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Extracellular signal regulated kinases, ERK, ERK1, ERK2, Inhibitor, inhibit, MK8353, MK-8353, MK 8353, SCH 900353, SCH900353, SCH-900353

Compound Identifiers

PubChem CID

58282870