Mito-TEMPO

SKU: orb1218924

Description

Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic. Mito-TEMPO with superoxide and alkyl radical scavenging properties.(In Vivo):Mito-TEMPO (MT) greatly attenuates the increase in ALT activities and reduces the areas of necrosis at both time points, indicating that the protection by Mito-TEMPO is sustained until at least 24 h post-APAP. Mito-Tempo could induce secondary apoptosis in the late phase of APAP hepatotoxicity. Mito-Tempo induces secondary apoptosis after APAP overdose by inhibition of RIP3.

Key Properties

• CAS Number: 1334850-99-5
• MW: 510.03
• Purity: >98% (HPLC)
• Formula: C₂₉H₃₅ClN₂O₂P
• SMILES: [O]N1C(C)(C)CC(NC(C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC1(C)C.[Cl-]
• Target: Mitochondrial Metabolism
• Solubility: DMSO:125 mg/mL (245.08 mM; Need ultrasonic);H2O:60 mg/mL (117.64 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Mito-TEMPO (MT) greatly attenuates the increase in ALT activities and reduces the areas of necrosis at both time points, indicating that the protection by Mito-TEMPO is sustained until at least 24 h post-APAP. Mito-Tempo could induce secondary apoptosis in the late phase of APAP hepatotoxicity. Mito-Tempo induces secondary apoptosis after APAP overdose by inhibition of RIP3.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Mitochondrial Metabolism