Metformin

SKU: orb1220037

Description

Metformin is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.Metformin is a first-line drug for the treatment of type 2 diabetes (T2D) and is often prescribed in combination with other drugs to control a patient's blood glucose level and achieve their HbA1c goal.(In Vitro):Metformin (1,1-Dimethylbiguanide) inhibits proliferation of ESCs in a concentration-dependent manner. The IC50 is 2.45 mM for A-ESCs and 7.87 mM for N-ESCs. Metformin shows pronounced effects on activation of AMPK signaling in A-ESCs from secretory phase than in cells from proliferative phase.Metformin (0-500 μM) decreases glycogen synthesis in a dose-dependent manner with an IC50 value of 196.5 μM in cultured rat hepatocytes.Metformin shows cell viability and cytotoxic effects on PC-3 cells with IC50 of 5 mM.(In Vivo):Metformin (1,1-Dimethylbiguanide; 100 mg/kg, p.o.) alone, and metformin (25, 50, 100 mg/kg) with isoproterenol groups attenuates myocyte necrosis through histopathological analysis.Metformin (> 900 mg/kg/day, p.o.) results in moribundity/mortality and clinical signs of toxicity in Crl:CD(SD) rats.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 657-24-9
• MW: 129.16
• Purity: >98% (HPLC)
• Formula: C₄H₁₁N₅
• SMILES: CN(C)C(=N)NC(N)=N
• Target: AMPK
• Solubility: In Vitro: H2O : 50 mg/mL (387.12 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1,1-Dimethylbiguanide

Quick Database Links

Gene Symbol

AMPK