Menadione

SKU: orb1310604

Description

Menadione (Vitamin K3) is a synthetic provitamin lacking the isoprenoid side chain. It serves as a precursor, being alkylated in vivo to form biologically active menaquinone (Vitamin K2). This compound is used in research on coagulation, bone metabolism, and oxidative stress in both cellular and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 58-27-5
• MW: 172.18
• Purity: 97.64% (May vary between batches)
• Formula: C₁₁H₈O₂
• SMILES: O=C1C=2C(C(=O)C=C1C)=CC=CC2
• Target: Thrombin|||Endogenous Metabolite
• Solubility: DMSO:64.4 mg/mL (374.03 mM);Ethanol:32 mg/mL (185.85 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (11.62 mM)

Bioactivity

• In Vivo:
  In AR4-2J cells, Menadione (1-20 mM) inhibits cell proliferation in a dose- and time-dependent manner. In the RALA255-10G rat liver cell line, Menadione activates extracellular signal-regulated kinase and c-Jun N-terminal kinase. Furthermore, Menadione suppresses multidrug-resistant leukemia cell lines (IC50=13.5 mM) and primary leukemia cell lines (IC50=18 mM). At 100 mM, Menadione induces DNA fragmentation, leading to rapid cell death. Additionally, in normal pancreatic acinar cells, Menadione inhibits mitochondrial Ca(2+) uptake.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Endogenous Metabolite, Menadione, EndogenousMetabolite, inhibit, Inhibitor, Thrombin, Vitamin K3, Vitamin K-3, vitamin K, Vitamin K 3

Compound Identifiers

PubChem CID

4055