MEISi-2

SKU: orb1685326

Description

MEISi-2

Key Properties

• CAS Number: 2250156-71-7
• MW: 306.32
• Formula: C₁₈H₁₄N₂O₃
• SMILES: C(\NNC(=O)C1=CC=C(O)C=C1)=C\2/C=3C(C=CC2=O)=CC=CC3
• Target: Others
• Solubility: DMSO:80 mg/mL (261.16 mM)

Bioactivity

• In Vivo:
  In a mouse model, MEISi-2 (at a concentration of 10µM) was administered intraperitoneally on days 1, 4, and 7 (100µL per injection), and bone marrow cells were collected on day 10 for analysis. The Results showed that this treatment significantly upregulated the expression of hematopoietic stem cell markers c-Kit+ and Sca-1+, with the numbers of c-Kit+, Sca-1+, and LSKCD34lowHSC cells increasing approximately 2-fold, 1.5-fold, and 3-fold, respectively. Meanwhile, MEISi-2 treatment downregulated the expression of key cell cycle inhibitors such as Meis1, Hif-2α, and p16. The study indicates that MEISi-2 effectively inhibits MEIS protein function and promotes an increase in hematopoietic stem cell numbers by modulating gene expression.
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• In Vitro:
  In studies of neonatal rat cardiomyocytes (RNCMs) and human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes, treatment with MEISi-2 (5 μM) was performed. In RNCMs, the proportion of cells positive for the proliferation markers phospho-histone H3 (Ph3) and Aurora B significantly increased following treatment. Specifically, the proliferation rate of Ph3⁺/TnnT2⁺ cells increased by up to 4.5-fold, while the proportion of Aurora B⁺/TnnT2⁺ cells doubled. Meanwhile, the expression levels of MEIS1 target genes, including Hif-1α, Hif-2α, and p21, were significantly downregulated .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Benzoic acid, 4-hydroxy-, 2-[(Z)-(2-oxo-1(2H)-naphthalenylidene)methyl]hydrazide, cardiac, cancer, bone, inhibit, issues, marrow, MEIS, meis1, MEISi 2, MEISi2, MEISi-2, injuries, Inhibitor, hematopoiesis, transplantations, TALE

Compound Identifiers

PubChem CID

796742