MEISi-2

SKU: orb1218391

Description

MEISi-2 is a potent MEIS inhibitor (MEISi). MEISi-2 significantly inhibits MEIS-luciferase reporters in vitro.

Key Properties

• CAS Number: 2250156-71-7
• MW: 306.32
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₄N₂O₃
• SMILES: O=C(NN/C=C1C(C=CC2=C\1C=CC=C2)=O)C3=CC=C(O)C=C3
• Target: MEIS
• Solubility: In Vitro: H2O : < 0.1 mg/mL (insoluble))

Bioactivity

• In Vivo:
  MEISi-2 (10 μM; i.p.; at day 1, day 4 and day 7) functionally inhibits MEIS In vivo, thus they induces c-Kit+ cell, Sca1+ cell, CD150+ cell, LSK HSPCs, LSKCD34low HSC content and LSKCD150+CD48-HSC content. MEISi-2 down-regulates Meis1 expression, Hif-2α, and key CDKI gene expression including p16, p19, p19ARF. Animal model: 4-6 week-old BALB/c mice. Dosage: 10 μM/100 μL. Administration: Intraperitoneal injection, at day 1, day 4 and day 7. Result: Modulated HSC pool.
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• In Vitro:
  MEISi-2 does not significantly inhibit the PBX-Luc-reporter. MEISi-2 induces MEIS dependent hematopoietic stem cell maintenance and self-renewal. MEISi-2 down-regulates MEIS target gene expression. MEISi-2 induces murine (LSKCD34low cells) and human (CD34+, CD133+, and ALDHhi cells) HSC self-renewal ex vivo.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Benzoic acid, 4-hydroxy-, 2-[(Z)-(2-oxo-1(2H)-naphthalenylidene)methyl]hydrazide

Quick Database Links

Gene Symbol

MEIS