MC3817

SKU: orb3174384

Description

MC3817 is a selective DNMT inhibitor, with IC50 values of 0.044 μM for DNMT1 and greater than 10 μM for DNMT3A/3L. It inhibits P53-dependent cancer cell proliferation, induces apoptosis and DNA damage, and elevates the levels of cleaved Caspase 3, P53, and γH2AX. MC3817 is applicable in research on non-small cell lung cancer, colon cancer, cervical cancer, triple-negative breast cancer, and histiocytic lymphoma.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry

Key Properties

• MW: 685.10
• Formula: C₃₃H₄₀Cl₃N₉O
• SMILES: CN(CC1=CC(NC(C2=CC(CN(C)C)=CC(NC3=CC=NC4=CC=CC=C34)=C2)=O)=CC(NC5=NC(N)=NC(C)=C5)=C1)C.Cl.Cl.Cl
• Target: DNA Methyltransferase,MDM-2/p53,Apoptosis,Caspase,DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DNA Methyltransferase,MDM-2/p53,Apoptosis,Caspase,DNA/RNA Synthesis