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MC3817 free base

SKU: orb3210070

Description

MC3817 free base is a selective DNMT inhibitor with an IC50 value of 0.044 μM for DNMT1 and greater than 10 μM for DNMT3A/3L. It suppresses P53-dependent cancer cell proliferation, induces apoptosis and DNA damage, and increases the levels of cleaved Caspase 3, P53, and γH2AX. MC3817 free base is applicable in research related to non-small cell lung cancer, colon cancer, cervical cancer, triple-negative breast cancer, and histiocytic lymphoma.

Images & Validation

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MC3817 free base

Key Properties

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TargetDNA/RNA Synthesis,DNA Methyltransferase,MDM-2/p53,Apoptosis,Caspase

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Quick Database Links

Gene Symbol
DNA/RNA Synthesis,DNA Methyltransferase,MDM-2/p53,Apoptosis,Caspase

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