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MBP Antibody / Myelin Basic Protein

Catalog Number: orb699741

DispatchUsually dispatched within 5-10 working days
$ 410.00
Catalog Numberorb699741
CategoryAntibodies
DescriptionMyelin basic protein (MBP) is the second most abundant protein in central nervous system (CNS) myelin: it comprises 30% of the total protein and about 10% of the dry weight of myelin. It is the only structural protein found so far to be essential for formation of CNS myelin, and has been called the executive molecule of myelin . MBP can interact with a number of polyanionic proteins including actin, tubulin, calmodulin, and clathrin, and negatively charged lipids, and acquires structure on binding to them. It may act as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin. MBP may be applicable as a marker for oligodendrogliomas. MBP/4271 recognizes an epitope in the 129-138 region of MBP, useful in clinical diagnosis to detect MBP levels.
Species/HostMouse
ClonalityMonoclonal
Clone NumberMBP/4271
Tested applicationsIHC-P, WB
ReactivityHuman
IsotypeMouse IgG2a
ImmunogenThe epitope for this MBP antibody has been mapped to amino acids 129-138 from the human protein.
Antibody TypePrimary Antibody
Dilution rangeWestern blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT
PurityProtein G affinity chromatography
ConjugationUnconjugated
Formula0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Hazard InformationThis MBP antibody is available for research use only.
UniProt IDP02686
StorageStore the MBP antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Buffer/Preservatives0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced), 0.05% sodium azide
NoteFor research use only
Application notesOptimal dilution of the MBP antibody should be determined by the researcher.
Expiration Date12 months from date of receipt.
MBP Antibody / Myelin Basic Protein

IHC staining of FFPE human brain with MBP antibody. HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

MBP Antibody / Myelin Basic Protein

IHC staining of FFPE human brain with MBP antibody. HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

MBP Antibody / Myelin Basic Protein

Western blot testing of human brain lysate with MBP antibody. Isoforms may be visualized from 20~37 kDa.

MBP Antibody / Myelin Basic Protein

SDS-PAGE analysis of purified, BSA-free MBP antibody as confirmation of integrity and purity.

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    Human

    Mouse

    Monoclonal

    Unconjugated

    20 μg
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    IHC-P,  WB

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    Mouse

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    IHC-P,  WB

    Human

    Mouse

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  • MBP Antibody / Myelin Basic Protein [orb699743]

    IHC-P,  WB

    Human, Mouse

    Rat

    Monoclonal

    Unconjugated

    20 μg