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MBP Antibody / Myelin Basic Protein

Catalog Number: orb699549

DispatchUsually dispatched within 5-10 working days
$ 410.00
Catalog Numberorb699549
CategoryAntibodies
DescriptionMyelin basic protein (MBP) is the second most abundant protein in central nervous system (CNS) myelin: it comprises 30% of the total protein and about 10% of the dry weight of myelin. It is the only structural protein found so far to be essential for formation of CNS myelin, and has been called the executive molecule of myelin . MBP can interact with a number of polyanionic proteins including actin, tubulin, calmodulin, and clathrin, and negatively charged lipids, and acquires structure on binding to them. It may act as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin. MBP may be applicable as a marker for oligodendrogliomas.
Species/HostRabbit
ClonalityRecombinant
Clone NumberMBP/4277R
Tested applicationsIHC-P
ReactivityHuman
IsotypeRabbit IgG
ImmunogenA portion of amino acids 150-250 from the human protein was used as the immunogen for the recombinant Myelin Basic Protein antibody.
Antibody TypePrimary Antibody
Dilution rangeImmunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT
PurityProtein A affinity chromatography
ConjugationUnconjugated
Formula0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Hazard InformationThis recombinant Myelin Basic Protein antibody is available for research use only.
UniProt IDP02686
StorageStore the recombinant Myelin Basic Protein antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Buffer/Preservatives0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced), 0.05% sodium azide
NoteFor research use only
Application notesOptimal dilution of the recombinant Myelin Basic Protein antibody should be determined by the researcher.
Expiration Date12 months from date of receipt.
MBP Antibody / Myelin Basic Protein

IHC staining of FFPE human brain with recombinant Myelin Basic Protein antibody (clone MBP/4277R). HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

MBP Antibody / Myelin Basic Protein

IHC staining of FFPE human brain with recombinant Myelin Basic Protein antibody (clone MBP/4277R). HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

MBP Antibody / Myelin Basic Protein

Analysis of HuProt (TM) microarray containing more than 19000 full-length human proteins using recombinant Myelin Basic Protein antibody (clone MBP/4277R). These results demonstrate the foremost specificity of the MBP/4277R mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.

MBP Antibody / Myelin Basic Protein

SDS-PAGE analysis of purified, BSA-free recombinant Myelin Basic Protein antibody (clone MBP/4277R) as confirmation of integrity and purity.

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