MBCQ

SKU: orb1306141

Description

MBCQ is a selective PDE5 inhibitor used in biochemical research to study cGMP signaling pathways. It is a valuable tool for in vitro assays investigating erectile dysfunction and pulmonary hypertension, as well as for exploring PDE5's role in cellular regulation.

Research Area

Metabolism Research

Key Properties

• CAS Number: 150450-53-6
• MW: 313.74
• Purity: 99.45% (May vary between batches)
• Formula: C₁₆H₁₂ClN₃O₂
• SMILES: Clc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
• Target: PDE
• Solubility: DMSO:25 mg/mL (79.68 mM);10% DMSO+90% Corn Oil:2 mg/mL (6.37 mM)

Bioactivity

• Target IC50:
  PDE3:>100 μM (IC50)|PDE2:>100 μM (IC50)|PDE1:>100 μM (IC50)|PDE4:>100 μM (IC50)|PDE5:19 nM (IC50)
• In Vitro:
  MBCQ, a selective PDE5 inhibitor, significantly decreased the EC(50) values for GTN-induced relaxation in both tolerant and nontolerant tissues, but with the greatest relative shift occurring in tolerant veins.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PDE5, PGF2α, phosphodiesterase, Phosphodiesterase (PDE), Inhibitor, MBCQ, inhibit, coronary, cGMP-PDE, arteries

Compound Identifiers

PubChem CID

6610310