MBCQ

SKU: orb1219255

Description

MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.MBCQ, a selective PDE5 inhibitor, significantly decreased the EC(50) values for GTN-induced relaxation in both tolerant and nontolerant tissues, but with the greatest relative shift occurring in tolerant veins.

Key Properties

• CAS Number: 150450-53-6
• MW: 313.74
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₂ClN₃O₂
• SMILES: ClC1=CC2=C(N=CN=C2NCC3=CC=C(OCO4)C4=C3)C=C1
• Target: PDE
• Solubility: In Vitro: DMSO : 100 mg/mL (318.74 mM)

Bioactivity

• In Vitro:
  MBCQ (compound 3d) induces relaxation of isolated porcine coronary arteries precontracted with prostaglandin F2α (PGF2α; EC50 = 190 nM). MBCQ (0.01-10 μM; 10 min) inhibits Carbachol (10 μM)-induced contractions in a concentration-dependent manner in rat ileal smooth muscle.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PDE