Maytansinol

SKU: orb1308059

Description

Maytansinol (Ansamitocin P-0) is a microtubule-destabilizing agent that disrupts microtubule polymerization in vitro. This mechanism supports its research use as a cytotoxic payload in antibody-drug conjugates (ADCs) and in studying mitosis and cell proliferation in cancer research models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 57103-68-1
• MW: 565.05
• Purity: 98.80% (May vary between batches)
• Formula: C₂₈H₃₇ClN₂O₈
• SMILES: C[C@]12[C@@](O1)([C@H](C)[C@@]3(C[C@](O)([C@H](OC)/C=C/C=C(\C)/CC4=CC(N(C)C(=O)C[C@@H]2O)=C(Cl)C(OC)=C4)NC(=O)O3)[H])[H]
• Target: Apoptosis,ADC Cytotoxin,Microtubule Associated
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.54 mM);DMSO:35 mg/mL (61.94 mM)

Bioactivity

• In Vitro:
  Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol causes apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to the drug. Maytansinol decreases the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ansamitocin P 0, Ansamitocin P0, Ansamitocin P-0, Apoptosis, ADCCytotoxin, ADC Payload, ADC Cytotoxin, Microtubule Associated, MicrotubuleAssociated, Microtubule/Tubulin, inhibit, Inhibitor, Maytansinoids, Maytansinol

Compound Identifiers

PubChem CID

131855304