Marein

SKU: orb1297290

Description

Marein demonstrates neuroprotective properties against methylglyoxal-induced damage in PC12 cells by preserving mitochondrial function and activating the AMPK pathway. This suggests its potential application in researching diabetic encephalopathy, supported by in vitro studies investigating neuroprotection mechanisms.

Research Area

Epigenetics & Chromatin, Metabolism Research, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 535-96-6
• MW: 450.39
• Purity: 99.84% (May vary between batches)
• Formula: C₂₁H₂₂O₁₁
• SMILES: OC[C@H]1O[C@@H](Oc2ccc(C(=O)\C=C\c3ccc(O)c(O)c3)c(O)c2O)[C@H](O)[C@@H](O)[C@@H]1O
• Target: AMPK,HDAC,transporter,Akt
• Solubility: DMSO:60 mg/mL (133.22 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.44 mM)

Bioactivity

• Target IC50:
  HDAC:100 µM (IC50)
• In Vitro:
  To clarify whether Marein, a major compound from the hypoglycemic plant Coreopsis tinctoria, prevents PC12 cell damage induced by MG, we cultured PC12 cells in the presence of MG and Marein. Marein attenuated MG-induced changes in the mitochondrial membrane potential (ΔΨm), mitochondrial permeability transition pores (mPTPs), intracellular Ca2+ levels, the production of reactive oxygen species (ROS), glutathione (GSH)/glutathione disulfide (GSSG) and adenosine triphosphate (ATP), and the increase in the percentage of apoptotic cells. Marein also increased glyoxalase I (Glo1) activity, phospho-AMPKα± (Thr172) and Bcl-2 expression and diminished the activation of Bax, caspase-3 and inhibitor of caspase-activated deoxyribonuclease (ICAD). Importantly, pretreatment of cells with Marein diminished the compound C-induced inactivation of p-AMPK. Molecular docking simulation showed that Marein interacted with the γ subunit of AMPK

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CaMKK, antioxidative, antihyperlipidemic, antihypertensive, antidiabetic, AMPK, AMP-activated protein kinase, Akt, Histone deacetylases, Marein, HDAC, FoxO1, glycoside, GLUT, GLUT1, GSK-3β, neuroprotective, IRS, inhibit, Inhibitor

Compound Identifiers

PubChem CID

6441269