Mardepodect

SKU: orb1307898

Description

Mardepodect (PF-2545920) is a highly potent and selective PDE10A inhibitor (IC50 = 0.37 nM) with potential application in schizophrenia research. Its ability to cross the blood-brain barrier allows for in vivo studies to investigate its effects on striatal signaling and behavior in preclinical models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 898562-94-2
• MW: 392.45
• Purity: 98.82% (May vary between batches)
• Formula: C₂₅H₂₀N₄O
• SMILES: Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1
• Target: PDE
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.1 mM);DMSO:45 mg/mL (114.66 mM)

Bioactivity

• Target IC50:
  PDE10A:0.37 nM
• In Vivo:
  Mardepodect is active in a range of antipsychotic models with the ED50 of 1 mg/kg, antagonizing apomorphine-induced climbing in mice, inhibiting conditioned avoidance responding in both rats and mice, and blocking N-methyl-D-aspartate antagonist-induced deficits in prepulse inhibition of acoustic startle response in rats, while improving baseline sensory gating in mice.Mardepodect induces a dose-dependent increase in striatal cGMP in mice.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Mardepodect, PDE10A, inhibit, Phosphodiesterase (PDE), PF2545920, PF-2545920, PF-02545920, PF 2545920

Compound Identifiers

PubChem CID

11581936