[11C]MP 10

SKU: orb1301125

Description

[11C]MP 10 (PF-2545920) is a highly potent and selective inhibitor of PDE10A, exhibiting an IC50 of 0.37 nM and >1000-fold selectivity over other PDEs. This radiolabeled tracer is used in preclinical and clinical PET imaging studies to investigate PDE10A expression and occupancy in the brain for neurological and psychiatric research.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1292799-56-4
• MW: 391.45
• Purity: 99.50% (May vary between batches)
• Formula: C₂₅H₂₀N₄O
• SMILES: [11CH3]N1N=C(C(=C1)C=2C=CN=CC2)C3=CC=C(OCC4=NC5=C(C=C4)C=CC=C5)C=C3
• Target: PDE
• Solubility: Ethanol:69 mg/mL (176.27 mM);DMSO:79 mg/mL (201.81 mM)

Bioactivity

• Target IC50:
  PDE10A:0.37 nM
• In Vitro:
  PF-2545920 shows excellent potency and specificity in PDE10A with IC50 of 1.26 nM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

[11C]MP 10, PDE10A, Mardepodect, PF2545920, PF-2545920, PF 2545920

Compound Identifiers

PubChem CID

51351520