Maprotiline hydrochloride

SKU: orb1310873

Description

Maprotiline hydrochloride

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 10347-81-6
• MW: 313.864
• Purity: 99.84%
• Formula: C₂₀H₂₄ClN
• SMILES: Cl.CNCCCC12CCC(c3ccccc13)c1ccccc21
• Target: Adrenergic Receptor,Histamine Receptor,5-HT Receptor,AChR,Autophagy,Norepinephrine
• Solubility: Ethanol:23 mg/mL (73.28 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.37 mM);DMSO:98 mg/mL (312.24 mM)

Bioactivity

• In Vivo:
  Maprotiline results in significantly increases GluR1 and GluR2/3 subunit expression in the nucleus accumbens and dorsal striatum of mice as detected by immunohistochemistry; and significantly increases GluR1 and GluR2/3 expression in the hippocampus, as demonstrated by Western blot analysis. Maprotiline has a potent anti-inflammatory effect in rats and this effect is linked to the peripheral and supraspinal actions of the drug. Maprotiline impairs learning when administered before training, but no statistically significant effect is evident when administered after training.
• In Vitro:
  Maprotiline inhibits HERG channels expressed in HEK cells with an IC50 of 5.2 μM and HERG channels expressed in oocytes with an IC50 of 24 μM. Maprotiline blocks open channels but has no significant effect on closed channels. Maprotiline is atetracyclic antidepressant, which strongly inhibits the uptake of noradrenaline, though it is notable in its lack of inhibition of serotonergic uptake. Maprotiline also has markedly less pronounced alpha-adrenergic blocking activity than amitriptyline. Maprotiline decreases cell viability in a concentration- and time-dependent manner in Neuro-2a cells. Maprotiline induces apoptosis and increases caspase-3 activation. Maprotiline also induces [Ca(2+)](i) increases which involves the mobilization of intracellular Ca(2+) stored in the endoplasmic reticulum.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Deprilept, AdrenergicReceptor, Adrenergic Receptor, 5HT Receptor, 5-HT, 5HTReceptor, Autophagy, inhibit, Noradrenaline transporter (Sodium-dependent), Inhibitor, Ludiomil, mAChR, Maprotiline, Maprotiline HCl, Maprotiline Hydrochloride, Maprotiline hydrochloride, HistamineReceptor, Histamine Receptor, H1 receptor, Psymion

Compound Identifiers

PubChem CID

71478